16:05
PL04 - Affinity Selection-Mass Spectrometry for Oligonucleotides, Proteins, Cells, and Animals
Prof. Bradley Lether PENTELUTE
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, United States
Bradley L. Pentelute, Professor of Chemistry. He is also an Associate Member, Broad Institute of Harvard and MIT, an Extramural Member of the MIT Koch Cancer Institute, and Member, Center for Environmental Health Sciences MIT. He received his undergraduate degree in Psychology and Chemistry from the University of Southern California, and his M.S and Ph.D. in Organic Chemistry from the University of Chicago with Prof. Steve Kent. He was a postdoctoral fellow in the laboratory of Dr. R. John Collier at Harvard Medical School, Microbiology.
16:40
PL05 - Affinity Selection Mass Spectrometry (ASMS) for Experimental Target Tractability Assessment (eTA)
Dr Lauren KUSTIGIAN
GSK, Collegeville, PA, United States
Lauren Kustigian, Ph.D. is an Investigator in the Screening Profiling and Mechanist Biology group at GSK. Her work at GSK primarily focuses on the development and implementation of the Affinity Selection Mass Spectrometry platform for early-stage drug discovery. Lauren started her career at Mirobiotix Inc, where she focused on identifying novel compounds which inhibited DNA replication proteins. She joined Sirtris Pharmaceuticals in 2009 as an enzymologist. At Sirtris she worked to develop new assays to identify modulators of sirtuin activity and the mechanism in which those compounds work. From there she joined the biochemistry department at Texas A&M University, where her she studied the membrane fission proteins using a single particle fluorescence-based method. Prior to joining GSK she worked as a post-doctoral researcher at Bondwell Technologies. Lauren received a Bachelor of Science in Biochemistry from the University of Massachusetts-Amherst in 2004, a Master’s degree in biotechnology from Worcester State University in 2010 and a Doctorate from Texas A&M University in 2019.
17:15
PL06 - Difficulties and Solutions Along the ASMS Data Analysis Pathway
Dr Mark SPEARS
VIRSCIDIAN, Cary, NC, United States
Mark Spears earned his PhD from the Georgia Institute of Technology in 2014 where his work focused on biocompatible polymer microstructures and assembly of these structures into surface coatings. Mark joined Wyatt Technology in 2015 as an applications scientist where he developed expertise in chromatography, laser light-scattering techniques and biophysical characterization of polymers and proteins; he also supported business development and sales activity in the southeastern United States. In 2018, Mark joined the protein formulation development group at Fujifilm Diosynth Biotechnologies in Research Triangle Park, NC. He worked extensively on automating the protein formulation development process through robotics, seamless laboratory data management, and novel approaches to formulation development programs.
Mark joined Virscidian Inc. in 2019 as a Senior Scientist where his roles include business development, scientific collaboration and guidance for customers, writing product documentation, and project management. He has a passion for delighting Virscidian’s customers and contributing to the scientific community by providing game-changing software solutions for LC-MS data management and processing
17:50
Break
18:00
Roundtable discussion & Closing remarks
Prof. Bradley Lether PENTELUTE
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, United States
Bradley L. Pentelute, Professor of Chemistry. He is also an Associate Member, Broad Institute of Harvard and MIT, an Extramural Member of the MIT Koch Cancer Institute, and Member, Center for Environmental Health Sciences MIT. He received his undergraduate degree in Psychology and Chemistry from the University of Southern California, and his M.S and Ph.D. in Organic Chemistry from the University of Chicago with Prof. Steve Kent. He was a postdoctoral fellow in the laboratory of Dr. R. John Collier at Harvard Medical School, Microbiology.
Dr Lauren KUSTIGIAN
GSK, Collegeville, PA, United States
Lauren Kustigian, Ph.D. is an Investigator in the Screening Profiling and Mechanist Biology group at GSK. Her work at GSK primarily focuses on the development and implementation of the Affinity Selection Mass Spectrometry platform for early-stage drug discovery. Lauren started her career at Mirobiotix Inc, where she focused on identifying novel compounds which inhibited DNA replication proteins. She joined Sirtris Pharmaceuticals in 2009 as an enzymologist. At Sirtris she worked to develop new assays to identify modulators of sirtuin activity and the mechanism in which those compounds work. From there she joined the biochemistry department at Texas A&M University, where her she studied the membrane fission proteins using a single particle fluorescence-based method. Prior to joining GSK she worked as a post-doctoral researcher at Bondwell Technologies. Lauren received a Bachelor of Science in Biochemistry from the University of Massachusetts-Amherst in 2004, a Master’s degree in biotechnology from Worcester State University in 2010 and a Doctorate from Texas A&M University in 2019.
Dr Mark SPEARS
VIRSCIDIAN, Cary, NC, United States
Mark Spears earned his PhD from the Georgia Institute of Technology in 2014 where his work focused on biocompatible polymer microstructures and assembly of these structures into surface coatings. Mark joined Wyatt Technology in 2015 as an applications scientist where he developed expertise in chromatography, laser light-scattering techniques and biophysical characterization of polymers and proteins; he also supported business development and sales activity in the southeastern United States. In 2018, Mark joined the protein formulation development group at Fujifilm Diosynth Biotechnologies in Research Triangle Park, NC. He worked extensively on automating the protein formulation development process through robotics, seamless laboratory data management, and novel approaches to formulation development programs.
Mark joined Virscidian Inc. in 2019 as a Senior Scientist where his roles include business development, scientific collaboration and guidance for customers, writing product documentation, and project management. He has a passion for delighting Virscidian’s customers and contributing to the scientific community by providing game-changing software solutions for LC-MS data management and processing
Dr Allen ANNIS
AILERON THERAPEUTICS, Cambridge, United States